productdatasheet
CatalogNo.:28104
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
F-boxproteins,criticalcomponentsoftheconservedubiquitin-proteinligasecomplexSCF(Skp1/Cdc53-Cullin1/F-box),recruitsubstratesforubiquitinationandconsequentdegradationthroughtheirspecificprotein-proteininteractiondomains.NovelhumanF-boxproteinsnamedFBG1,FBG2,FBG3,FBG4and
FBG5constituteasubfamilyofmammalianF-boxproteins.FBGgenesareexpressedinalimitednumberofhumantissuesincludingkidney,liver,brainandmuscletissues.
Immunogen:Syntheticpeptidecorrespondingtoaminoacids103-119(EWKVEDLSRDQRKEFPN)ofhuman
FBG3conjugatedtoKLHattheN-terminus.
HostSpecies:RabbitStABIlizers:NonePreservatives:None.Availableonrequest.
SPECIFICITYThisantibodyrecognizeshumanFBG3.SequencehomologytomouseandratFBG3is94%.
Immunoblotting:useat1:500dilution.Abandofapproximately31kDaisdetected.
Positivecontrol:recombinanthumanFBG3.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Ilyin,GPetal.(2002)Gene296:11-20.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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