CatalogNo.:56523(cloneS81-2)Size:100uginPBS(1mg/ml),pH7.4,50%glycerol,0.09%sodiumazide.

PurifiedbyProteinGaffinitychromatography.

GABA(γ-aminobutyricacid)istheprimaryinhibitoryneurotransmitterinthecentralnervoussystemandinteractswiththreedifferentreceptors:GABA(A),GABA(B),andGABA(C).GABA(B)receptoriscoupledtoGproteinsthatmodulateslowinhibitorysynaptictransmission.

FunctionalGABA(B)receptorsformheterodimersofGABA(B)R1andGABA(B)R2inwhichGABA(B)R1bindsaligandandGABA(B)R2istheprimaryGproteincontactsite.

Antigen:Fusionproteincorrespondingtoaa861-912ofratGABA(B)R2(accessionno.NP_113990.1).

HostSpecies:Mouse

AntibodyClass:IgG1

Thisantibodyrecognizeshuman,mouse,andratGABA(B)R2.Itdoesnotcross-reactwithGABA(B)R1.

Immunoblotting:useat1-2ug/ml.Abandof~105kDaisdetected.

Immunoblotonmouse(left)andrat(right)brainmembranes.

Immunohistochemistry:useat1-5ug/ml.Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.

Positivecontrol:Ratbrainmembranes.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisproductisstableforatleast1yearat

-20oC.Freezeinmultiplealiquotstoavoidrepeatedfreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.