productdatasheet

CatalogNo.:1133

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.

Glialcellline-derivedneurotrophicfactor(GDNF)isapotentsurvivalfactorforcentralandperipheralneuronsandisessentialforthedevelopmentofthekidneyandtheentericnervoussystem.

PhysiologicalresponsestoGDNFrequirethepresenceofanovelglycosylphosphatidylinositollinkedprotein,GDNFRα,acellsurfacereceptorforGDNF.TheCDNAsencodingGDNFRαfromhuman,rat,chicken,andmousehavebeencloned.GDNFRαhasalsobeenreferredtoasGFRα-1,Retligand1(RETL1)andTGF-β-relatedneurotrophicfactorreceptor1(TmR1).GFRα-1bindsGDNFspecificallyandmediatesactivationoftheRetproteintyrosinekinase(PTK).Thus,GDNF,GFRα,andtheRetPTKformacomplextotransmittheGDNFsignalandtomediateGDNFfunction.GFRα-1hasbeenidentifiedinbrain,liver,kidney,andspleen.

Antigen:Peptidecorrespondingtoaa369-382ofhumanGFRα-1.Thispeptidesequenceisidenticaltothoseofmouseandrat.

HostSpecies:Rabbit

StABIlizers:None

Preservatives:0.02%sodiumazide.

Thisantibodyrecognizeshuman,mouse,andratGFRα-1(approx.50kD).

Immunoblotting:useat1:500dilution.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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