productdatasheet

CatalogNo.:1135

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.

Membersoftheglialcellline-derivedneurotrophicfactor(GDNF)family,includingGDNFandneurturin(NTN),playkeyrolesinthecontrolofvertebrateneuronalsurvivialanddifferentiation.PhysiologicalresponsestoNTNrequirethepresenceofanovelglycosylphosphatidylinositollinkedprotein,NTNRα,whichisacellsurfacereceptorforNTN.TheCDNAsencodingNTNRαfromhuman,rat,chicken,andmousehavebeencloned.NTNRαhasalsobeenreferredtoasGFRα-2,GDNFRβ,Retligand2(RETL2),andTGF-β-relatedneurotrophicfactorreceptor2(TmR2).

GFRα-2bindsNTNandmediatesactivationofRETreceptortyrosinekinasebybothNTNandGDNF.Thus,NTN,GFRα-2,andtheRetPTKformacomplextotransmittheNTNsignalandtomediateNTNfunction.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

Antigen:Peptidecorrespondingtoaa377-391ofhumanGFRα-2.Thispeptidesequenceisidenticaltothoseofmouseandrat.

HostSpecies:Rabbit

StABIlizers:None

Preservatives:0.02%sodiumazide.

Thisantibodyrecognizeshuman,mouse,andratGFRα-2(52kD).

Immunoblotting:useat1:1,000-1:2,000dilution.

Positivecontrol:WholecelllysateofHeLacells.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

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