productdatasheet
CatalogNo.:1137
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
Membersoftheglialcellline-derivedneurotrophicfactor(GDNF)family,includingGDNFandneurturin(NTN),playkeyrolesinthecontrolofvertebrateneuronalsurvivialanddifferentiation.AnewmemberoftheGDNFfamilywasrecentlyidentifiedanddesignatedpersephin.Physiologicalresponsestotheseneurotrophicfactorsrequrietworeceptorsubunits,thenovelglycosylphosphatidylinositollinkedproteinGFRαandRetreceptortyrosinekinaseGFRβ.Followingtheidentificationof
GFRα-1and–2,anotherreceptorintheGFRfamilywasidentifiedinhumanandmouseanddesignatedGFRα-3.GFRα-3bindspersephin.Thus,persephin,GFRα-3,andRetPTKformacomplextotransmitthepersephinsignalandtomediatepersephinfunction.
SPECIFICATIONSUMMARYAntigen:Peptidecorrespondingtoaa347-360ofmouseGFRα-3.
HostSpecies:Rabbit
StABIlizers:None
Preservatives:0.02%sodiumazide.
Thisantibodyrecognizeshuman,mouse,andratGFRα-3(approx.43kD).
Immunoblotting:useat1:500-1:1,000dilution.
Positivecontrol:Tissuelysatesofmousekidney,liver,orheart.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
QEDBioscience,Inc.10919TechnologyPlace,SuiteC
SanDiego,CA92127
TollFree800.929.2114
Phone858.675.2405
Fax858.592.1509
info@qedbio.com
Visitourwebsiteforadditionalproductinformationandtoorderonline.
qedbio.com
