
GIT1MonoclonalAntibody
PurifiedbyProteinGaffinitychromatography.
G-proteincoupledreceptor(GPCR)kinaseinteractingproteins1and2(GIT1andGIT2)arehighlyconservedubiquitousscaffoldproteinsinvolvedinlocalizedsignalingtohelpregulatefocalcontactassemblyandcytoskeletaldynamics.GITproteinscontainmultipleinteractiondomainsforsmallGTPases,kinases,theRhofamilyGEFPIX,andthefocaladhesionproteinpaxillin.GIT1islocalizedtofocaladhesions,cyto-plasmiccomplexesandmembraneprotrusions,anditregulatescellprotrusionformationandcellmigration.
Thisantibodyrecognizeshuman,mouseandratGIT1.Itdoesnotcross-reactwithGIT2.
APPLICATIONSImmunoblotting:useat1ug/ml.Predictedmolecularweightis~90kDa.
Immunoblotonratbrainlysatewith#56537at1ug/ml.
PositiveControl:ratbrainlysate.
Thesearerecommendedconcentrations.Endusersshoulddetermineoptimalconcentrationsfortheirapplications.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notintendedfordiagnosticortherapeuticapplications.