productdatasheet
CatalogNo.:28103
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
Non-insulin-dependentdiabetesmellitus(NIDDM)isamultifactoraldiseasewithbothenvironmentalandgeneticcauses.Genome-widescreeninghasidentifiedseveralsusceptibilitylociforNIDDMwithinthehumangenome.Mostmammaliancellstransportglucosethroughafamilyofmembraneproteinsknownasglucosetransporters(GLUTorSLC2Afamily).ThegeneforGLUT10,localizedtohumanchromosome20q12-q13.1,isacandidategeneforNIDDMsusceptibility.Itiswidelyexpressed,withhighestlevelsinliverandpancreas.
Immunogen:Syntheticpeptidecorrespondingtoaminoacids367-385(ILSTAKKTKPHPRSGDPSA)ofhuman
GLUT10conjugatedtoKLHattheN-terminus.
HostSpecies:Rabbit
StABIlizers:NonePreservatives:None.Availableonrequest.
SPECIFICITYThisantibodyrecognizeshumanGLUT10.
Immunoblotting:useat1:500dilution.Abandofapproximately57kDaisdetected.
Positivecontrol:transfectedcelllysate
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Wood,IS,Hunter,LandTrayhurn,P(2003)BiochemBiophysResCommun308:43-49.
McVie-Wylie,AJ,Lamson,DRandChen,YT(2001)Genomics72:113-117.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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