productdatasheet
CatalogNo.:2335
Size:100ugIgGin200ulPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
NuclearfactorkappaB(NF-κB)isaubiquitoustranscriptionfactorandkeymediatorofgeneexpressionduringimmuneandinflammatoryresponses.NF-κBactivatesnumerousgenesinresponsetoextracellularstimuli,suchasIL-1,TNFα,andLPS.NF-κBisassociatedwithIκBincytoplasm,whichinhibitsNF-κBactivity.
IκBisphos-phorylatedbytheIκBkinase(IKK)complexwhichcontainsIKKα,IKKβ,andIKKε.AnovelmoleculeintheIKKcomplex,designatedIKKγ,interactswithIKKβandisrequiredfortheactivationofIKKcomplexandNF-κBbyLPS,PMA,TNF,andIL-1.IKKγalsobindstoRIPandNIKandmediatesTNF-inducedNF-κBactivation.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
SPECIFICATIONSUMMARYAntigen:Peptidecorrespondingtoaa400-416ofhumanIKKγ.This
sequenceisidenticaltothatofmouse.
HostSpecies:Rabbit
StABIlizers:None
Preservatives:0.02%sodiumazide.
Thisantibodyrecognizeshuman,mouse,andratIKKγ(52kD).Nocross-reactivitywithIKKα,IKKβorIKKε.
Immunoblotting:useat1:500-1:1,000dilution.
Positivecontrol:WholecelllysatefromHeLacells.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
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