productdatasheet
CatalogNo.:2129
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
Cellularresponsesinducedbythepro-inflammatorycytokineIL-1requiretwosubunitsoftheIL-1receptor,IL-1receptor1(IL-1R1)andIL-1receptoraccessoryprotein(IL-1RacP).IL-1RacPformsacomplexwithIL-1R1inresponsetoIL-1treatment.IL-1receptor-associatedkinase(IRAK)mediatesactivationofNF-κBinducingkinase(NIK)andNF-κBandassociateswiththeIL-1RcomplexthroughIL-1RacP.IL-1activationofstress-activatedproteinkinaseandofacidsphingomyelinasealsorequiresIL-1RacP.LikeIL-1R1,theIL-1RacPsubunitisessentialforIL-1mediatedcellularresponses.IL-1RacPisexpressedinavarietyoftissues.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
SPECIFICATIONSUMMARYAntigen:Peptidecorrespondingtoaa525-540ofhumanIL-1RAcP.ThesequenceisidenticaltothatofmouseandratIL-1RAcP.
HostSpecies:Rabbit
StABIlizers:None
Preservatives:0.02%sodiumazide.
Thisantibodyrecognizeshuman,mouse,andratIL-1RAcP(66kD).Nocross-reactivitywithothermembersoftheIL-1receptorfamily.
Immunoblotting:useat1:1,000-1:2,000dilution.
Positivecontrol:WholecelllysatefromHeLacells.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
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