productdatasheet
CatalogNo.:2123
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
Thepro-inflammatorycytokineIL-1inducescellularresponsesthroughtwosubunitsofitsreceptor,IL-1receptor1(IL-1R1)andIL-1receptoraccessoryprotein(IL-1RacP).
IL-1receptor-associatedkinase(IRAK)mediatesactivationofNF-κB,akeytranscriptionfactorthatmediatesinflammatoryandimmunerespones.AnovelmemberoftheIRAK/PellefamilywasrecentlyidentifiedanddesignatedIRAK2.BothIRAKandIRAK2associatewiththesubunitsoftheIL-1RcomplexafterIL-1bindingandleadtoNF-κBactivation.
IRAKsalsoassociatewithToll-likereceptor
(TLR)andthedominantnegativemutantsofIRAKsinhibitLPS-inducedNF-κBactivation.MembersoftheIRAK/PellefamilyplayacentralroleinIL-1RandTLR-mediatedinflammatoryresponses.IRAK2isexpressedinavarietyofhumantissues.
SPECIFICATIONSUMMARYAntigen:Peptidecorrespondingtoaa546-564ofhumanIRAK2.
HostSpecies:Rabbit
StABIlizers:None
Preservatives:0.02%sodiumazide.
Thisantibodyrecognizesfull-lengthhumanIRAK2(65kD).
Immunoblotting:useat1:500-1:1,000dilution.
Positivecontrol:WholecelllysatefromHeLacellsorK562cells.Nocross-reactivitywithIRAK.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures
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