
mGluR1/5GlutamateReceptorMonoclonalAntibody
Themetabotropicglutamatereceptors(mGluRs)areactivethroughanindirectmetabotropicprocess.TheyaremembersofthegroupCfamilyofG-protein-coupledreceptors,orGPCRs.Likeallglutamatereceptors,mGluRsbindglutamatewhichfunctionsasanexcitatoryneurotransmitter.Metabotropicglutamatereceptorsarenotionchannels.Instead,theyactivatebiochemicalcascades,leADIngtothemodificationofotherproteins.Thiscanleadtochangesinthesynapse'sexcitABIlity.EightdifferenttypesofmGluRs,designatedmGluR1tomGluR8,aredividedintogroupsI,II,andIII.Receptortypesaregroupedbasedonreceptorstructureandphysiologicalactivity.
Thisantibodyrecognizeshuman,mouse,andratmGluR1andmGluR5.
Immunoblotting:useat1ug/ml.Abandof
~130kDaisdetected.Smallerfragmentsduetoproteolysisaredetectedaswell.
Positivecontrol:Ratbrainlysate.
Thesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.