productdatasheet
CatalogNo.:2127
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
Cellularresponsesinducedbythepro-inflammatorycytokineIL-1requireIL-1receptorcomplex(IL-1R1andIL-1RacP).Recently,MyD88wasidentifiedasanadaptermoleculeintheIL-1signalingpathway.MyD88associateswithandrecruitsIRAKtotheIL-1receptor.DominantnegativemutantsofMyD88attenuateIL-1R-mediatedNF-κBactivation.MyD88alsofunctionsasaregulatormoleculeforIL-18receptorandhumanTollreceptor,membersoftheToll/IL-1Rfamilyofreceptors.TargeteddisruptionoftheMyD88generesultsinlossofcellularresponsestoIL-1andIL-18,andMyD88-deficientmicelackresponsestoLPSwhichrequireToll-likereceptors2and4(TLR2andTLR4)asthesignalingreceptors.MyD88isageneraladapterproteinfortheToll/IL-1RfamilyofreceptorsandplaysanimportantroleintheinflammatoryresponsesinducedbycytokinesIL-1,IL-18,andLPS.MyD88isexpressedinavarietyoftissues.
SPECIFICATIONSUMMARYAntigen:Peptidecorrespondingtoaa279-296ofhumanMyD88.ThesequenceisidenticaltothatofmouseMyD88.
HostSpecies:Rabbit
StABIlizers:None
Preservatives:0.02%sodiumazide.
ThisantibodyrecognizeshumanandmouseMyD88(35kD).
Immunoblotting:useat1:500-1:1,000dilution.
Positivecontrol:WholecelllysatefromJurkatcells.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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