productdatasheet
CatalogNo.:1121
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
Glialcellline-derivedneurotrophicfactor(GDNF)playsakeyroleintheconrolofvertebrateneuronsurvivalanddifferentiation.Anovelneurotrophicfactorwasrecentlyclonedfromhumanandmouseanddesignatedneurturin.(NTN).PhysiologicalresponsestoNTNrequirethepresenceofreceptortyrosinekinaseRETandanovelglycosylphosphatidylinositollinkedreceptorNTNRα.TheCDNASencodingNTNRαfromhuman,rat,chicken,andmousehavebeenclonedandreferredtoasGFRα-2,GDNFRβ,Retligand2(RETL2),andTGF-β-relatedneurotrophicfactorreceptor2(TmR2).NTNformsacomplexwithGFRα-2andtheRetPTKandactivatestheRETreceptortyrosinekinasepathway.BothNTNandGDNFcanactivatetheMAPkinaseandphosphatidylinositol3-kinasepathwaysandplayacriticalroleinthedevelopmentofmanyneuronalpopulations.
SPECIFICATIONSUMMARYAntigen:Peptidecorrespondingtoaa178-193ofhumanneurturin.
HostSpecies:Rabbit
StABIlizers:None
Preservatives:0.02%sodiumazide.
Thisantibodyrecognizeshuman,neurturin(14kD).
Immunoblotting:useat1:500dilution.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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