
OtoferlinMonoclonalAntibody
OtoferlinproteinistheproductoftheOTOFgene.Otoferlinispresentinthebrainandthecochleaoftheinnerearwheresoundisprocessed.HearingreliesonCa2+influx-drivenexocytosisofsynapticvesiclesattheribbon-typeactivezonesofhaircells.ThepresenceofseveralC2domainsinotoferlin,some
ofwhichbindCa2+,suggestthatotoferlin
isaCa2+sensorforfusionininnerhaircell(IHC)synapses.
Thisantibodyrecognizeshumanotoferlin.
APPLICATIONSImmunoblotting:useat1-5ug/ml.Abandof~220kDaisdetected.
Immunofluorescence:useat2-10ug/ml.
Otoferlinisdetectedinhaircellsoftheinnerearcristaampullaris(CA),utricularmacula(UM),andsaccularmacula(SM)with#90023.
Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.
Reconstituteindistilledwater.
Thisproductisstableforatleastone(1)yearat-20oCto-70oC.Reconstitutedproductshouldbestoredinappropriate
aliquotstoavoidrepeatedfreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.