productdatasheet
TheMAPKs(Mitogen-ActivatedProteinKinases)areprotein-serine/threoninekinaseswhichsignaltransductionpathwaysthatcontrolintracellulareventsincludingacuteresponsestohormonesandmajordevelopmentalchangesinorganisms.Uponactivation,p38αMAPKtranslocatesintothenucleuswhereitphosphorylatesoneormorenuclearsubstrates,effectingtranscriptionalchangesandothercellularprocessesinvolvedincellgrowth,division,differentiation,inflammation,anddeath.p38αMAPKisactivatedbychemicalstressinducersincludinghydrogenperoxide,heavymetals,anisomycin,sodiumsalicylate,lipopolysaccharide,andBIOLOGicalstresssignalssuchastumornecrosisfactor,interleukin-1,ionizingandUVirrADIation,hyperosmoticstressandchemotherapeuticdrugs.
Antigen:Recombinanthumanp38αMAPKexpressedinE.coli.
HostSpecies:MouseAntibodyClass:IgG1Preservatives:0.09%sodiumazideOtheradditives:50%glycerolSPECIFICITYThisantibodyrecognizeshumanp38αMAPK.
Immunoblotting:useat1ug/ml.Abandof
~38kDaisdetected.
Thesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.
Positivecontrol:Purifiedp38αMAPK.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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