productdatasheet
CatalogNo.:28107
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
PAPK(polyploidy-associatedproteinkinase)isanewmemberoftheSte20/germinalcenterkinasefamilythatmodulatescytoskeletalorganizationandcellsurvival.ActivationofadeathsignaltransductionpathwaymayresultinthestimulationofthePAPKpromoterwhichleadstoincreasedPAPKexpressionandprovidesanegativefeedbacksignalthatpreventscelldeath.AnothernameforthisproteinisALS2CR2(amyotrophiclateralsclerosis2chromosomeregioncandidate2,isoformA).
Nishigaki,Ketal.(2003)JBiolChem15:13520-30.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
SPECIFICATIONSUMMARYImmunogen:Syntheticpeptidecorrespondingtoaminoacids399-418(SPWSELEFQFPDDKDPVWEF)of
mousePAPKconjugatedtoKLHattheC-terminus.
HostSpecies:Rabbit
StABIlizers:NonePreservatives:None.Availableonrequest.
ThisantibodyrecognizesmousePAPK.SequencehomologywithhumanPAPKis60%.
Immunoblotting:useat1:250dilution.Abandofapproximately46-47kDaisdetected.
Positivecontrol:livertissuelysate.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
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