productdatasheet

CatalogNo.:28110

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.

PARK7isoneoffourchromosomalloci(PARK2,PARK6,PARK7andPARK9)

knowntobeassociatedwithautosomalrecessive,earlyonsetparkinsonism.PositionalcloningwithintherefinedPARK7criticalregionrecentlyidentifiedmutationsintheDJ-1geneinPARK7-linkedfamilies.MutationsinthePARK7/DJ-1genecauseautosomal-recessiveParkinsonsdisease.

Immunogen:Syntheticpeptidecorrespondingtoaminoacids167-189(AIVEALNGKEVAAQVKAPLVLKD)of

humanPARK7conjugatedtoKLHattheN-terminus.

HostSpecies:Rabbit

StABIlizers:NonePreservatives:None.Availableonrequest.

ThisantibodyrecognizeshumanandmousePARK7(DJ-1).SequencehomologytomouseandratDJ-1is82%.

Immunoblotting:useat1:500dilution.Abandofapproximately19kDaisdetected.

Positivecontrol:HEK293celllysateormousebraintissuelysate.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone

(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Bandmann,O(2004)Neurology62:357-

3588.

Hedrich,Ketal.(2004)Neurology62:389-94.

Bandopadhyay,Retal.(2004)Brain127:420-30.

BonifatiVetal.(2003)NeurolSci24:159-60.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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