productdatasheet
CatalogNo.:28116
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
MutationsinthePTEN-inducedkinase(PINK1)gene,whichislocatedwithinthePARK6locusonchromosome1p35-p36,haverecentlybeenidentifiedinpatientswithrecessiveearlyonsetParkinson’sdisease.DatasuggestthatPINK1maybethesecondmostcommoncausativegenenexttoparkininparkinsonismwiththerecessivemodeofinheritance.
Beilina,Aetal.(2005)ProcNatlAcadSciUSA102:5703-08.
Valente,EMetal.(2004)Science304:1158-60.
Rogaeva,Eetal.(2004)ArchNeurol61:1898-1904.
Hatano,Yetal.(2004)AnnNeurol56:424-27.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
SPECIFICATIONSUMMARYImmunogen:Syntheticpeptidecorrespondingtoaminoacids258-274(YRKSKRGPKQLAPHPNI)ofhuman
PINK1conjugatedtoKLH.HostSpecies:RabbitStABIlizers:None
Preservatives:None.Availableonrequest.
ThisantibodyrecognizeshumanPINK1.
Immunoblotting:useat1:500dilution.Abandofapproximately62-63kDaisdetected.
Positivecontrol:transfectedcelllines.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
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