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Rab5isamemberoftheRabfamily,Rassuperfamily,ofsmallguanosinetriphosphatases(GTPases)andisexpressedinallhumantissues.RabGTPasesareregulatorsofmembranetraffickingineukaryoticcells.TheirregulatorycapacitydependsontheirABIlitytocyclebetweentheGDP-boundinactiveandGTP-boundactivestates.ActivationofaRabproteiniscoupledtoitsassociationwithintracellularmembranes,allowingittorecruitdownstreameffectorproteinstothecytoplasmicsurfaceofasubcellularcompartment.Throughtheseproteins,RabGTPasesregulatevesicleformation,acitn-andtubulin-dependentvesiclemovementandmembranefusion.Rabaptin-5andEEA1areamongtheproteinsrecruitedbyactiveRab5.
SPECIFICATIONSUMMARYHostSpecies:RabbitAntigen:HumanRab5syntheticpeptide(identicaltocanineRab5)conjugatedtoKLHAntibodyClass:PolyclonalPreservatives:None.Thisantibodyrecognizeshuman,mouse,rat,bovine,andmonkeyRab5.Otherspecieshavenotbeentested.
Immunoblotting:useat1ug/ml.Abandof~24-26kDaisdetected.
Positivecontrol:HeLacelllysate.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidrepeatedfreezingandthawing.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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