productdatasheet
CatalogNo.:56217
Size:100ugin10mMPBS,pH7.4.
SMRT(SilencingMediatorforRetinoidandThyroidreceptors)isa168kDnuclearprotein.Nuclearhormonereceptorsaretranscriptionfactorsregulatedbyligandbinding.Intheabsenceofligand,thereisaphysicalinteractionbetweenthenuclearreceptorsthatdonotinteractwithHsp90andafamilyofcorepressorswhichincludesSMRT.SMRThelpstargethistonedeacetylasesandothercomponentsofamultiproteinrepressorcomplextothespecifictargetpromotertosilencegenetranscription.
Antigen:AKLH-conjugatedsyntheticpeptidederivedfromhumanSMRTcorrespondingtoaa994-1005
HostSpecies:MouseStABIlizers:NonePreservatives:None.Availableonrequest.
ThisantibodyrecognizeshumanSMRT.
ImmunoblottingandImmuno-precipitation:useat1-5ug/ml.
Positivecontrol:HBL100
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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