productdatasheet
CatalogNo.:28117
Size:100ugProteinG-purifiedantibodyinPBS,pH7.4.
BACKGROUNDTheSOXgenefamilyisdefinedbytheSry-relatedHMGboxdomainthatmediatessequence-specificDNAbinding.AvarietyoffunctionsareassociatedwiththeSOXproteinsduringdevelopment.SOX6isbelievedtoregulateembryonicdevelopmentanddeterminecellfate.MouseSOX6isexpressedintheCNSduringembryogenesis,butthisexpressiondecreasessignificantlyintheadultCNS.Inhumans,SOX6isexpressedinfetalbrainandingliomasbutonlyatverylowlevelsintheadultbrain.AdirectlinkbetweenSOX6expressionandmalignancyhasnotbeendemonstrated,soSOX6probablydoesnotpromoteproliferation,butitmayinducetransformationactivityintheearlystageofoncogenesisingliomas.
Immunogen:Syntheticpeptidecorrespondingtoaminoacids780-796ofhumanandmouseSOX6.
HostSpecies:Rabbit
AntibodyClass:Polyclonal
Preservatives:None.Availableonrequest.
ThisantibodyrecognizeshumanSOX6andispredictedtorecognizemouse,rat,andchimpanzeeSOX6basedon100%sequencehomology.
Immunoblotting:useat1-5ug/ml.Abandofapproximately93kDaisdetected.Thesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplications.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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