productdatasheet
CatalogNo.:2429
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
STATS(signaltransducersandactivatorsoftranscription)areafamilyofcytoplasmiclatenttranscriptionfactorsthatareactivatedtoregulategeneexpressioninresponsetoalargenumberofextracellularsignalingpolypeptidesincludingcytokines,interferons,andgrowthfactors.AfterphosphorylationbyJAKtyrosinekinases,STATsenterthenucleustoregulatetranscriptionofmanydifferentgenes.STAT1isactivatedbymanydifferentligandsincludingtheinterferonfamily,gp130family,andreceptportyrosinekinases.STAT1hastwoforms,the91kDSTAT1αandthe84kDSTAT1β,whichareencodedbythesamegenewithsplicingvariant.
SPECIFICATIONSUMMARYAntigen:Peptidecorrespondingtoaa712-750ofhumanSTAT1α.
HostSpecies:Rabbit
StABIlizers:None
Preservatives:0.02%sodiumazide.
Thisantibodyrecognizesfull-lengthSTAT1α(91kD)anddoesnotreactwithSTAT1β.
APPLICATIONSImmunoblotting:usea1:1,000dilution.Immunoprecipitation:use2-4ugantibodypersample.
Positivecontrol:WholecelllysatefromHeLacells,Jurkatcells,orA431cells.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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