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CatalogNo.:56471(cloneEP10)Size:100uginPBS,pH7.4;50%

glycerol,0.09%sodiumazide.PurifiedbyProteinGaffinitychromatography.

Synaptophysinisasynapticvesicleglycoproteinwithfourtransmembranedomains.ItispresentinneuroendocrinecellsandisaspecificpresynapticMarkerforallneurons,neuroendocrinecells,andneoplasmsofneuroendocrineorigin.

Synaptophysinplaysaroleinsynapticvesicleexocytosisincludingcholesterol-dependentvesiclebiogenesis,regulationofSNAREassemblyviainteractionwithVAMP/synaptobrevin,formationofthefusionporeinitiatingneurotransmitterrelease,andactivationofvesicleendocytosis.ThegeneforsynaptophysinhasbeenimplicatedinX-linkedmentalretardation.

Thisantibodyrecognizeshumansynaptophysin.

Immunoblotting:useat1-10ug/ml.Abandof~38kDaisdetected.

1:MWmarkers;2:Humanbrainextract(10ug)

Positivecontrol:Humanbrainlysate.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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