Synaptotagmin-9MonoclonalAntibody
PurifiedbyProteinGaffinitychromatography.
SynaptotagminsconstituteafamilyofmembranetraffickingproteinsthatarecharacterizedbyanNterminaltrans-membraneregion(TMR),avariablelinker,andtwoC-terminalC2domains:C2AandC2B.Thereare15membersinthemammaliansynaptotagminfamily.
ThesynaptotagminsareintegralmembraneproteinsofsynapticvesiclesthoughttoactasCa+2sensorsinvesiculartraffickingandexocytosis.
Calciumbindingtosynaptotagmintriggersneurotransmitterreleaseatthesynapse.ThefirstC2domainmediatesCa+2-dependentphospholipidbinding.ThesecondC2domainmediatesinteractionwithStonin2.
Thisantibodyrecognizeshuman,mouse,andratSynaptotagmin-9.Itdoesnotcross-reactwithotherSynaptotagmins.
Immunoblotting:useat1ug/ml.Predictedmolecularweightis~60kDa.
PositiveControl:ratbrainlysate.
Thesearerecommendedconcentrations.Endusersshoulddetermineoptimalconcentrationsfortheirapplications.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notintendedfordiagnosticortherapeuticapplications.