ADVANCEDRESEARCHTECHNOLOGIES
CatalogNo.:56479(cloneSP6)Size:100uginPBS,pH7.4;50%
glycerol,0.09%sodiumazide.PurifiedbyProteinGaffinitychromatography.
BACKGROUNDSyntaxinisa~38kDatypeIIintegralmembraneproteinlocalizedtotheplasmamembraneatnerveterminals.SyntaxinwasidentifiedthroughitsassociationwithsynaptotagminandN-typecalciumchannel,asubtypeofcalciumchannelontheplasmamembranethatisimportantforneurotransmitterrelease.Homologsofsyntaxinhavebeenidentifiedinvariouseukaryotesrangingfromyeasttohuman.SyntaxinisalsothetargetofclostridialneurotoxinC1thatblocksneurotransmitterrelease.
Antigen:Synapticvesicle-containingfractionspurifiedfromhumanbrainextracts.
HostSpecies:Mouse
AntibodyClass:IgG1
Thisantibodyrecognizeshuman,mouse,rat,hamster,bovine,feline,andporcinesyntaxin.
Immunoblotting:useat1-10ug/ml.Abandof~38kDaisdetected.
Thesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.
Positivecontrol:Ratbrainlysate.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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