productdatasheet
CatalogNo.:56501
Size:50ugpurifiedbyion-exchangechromatographyinPBScontaining0.02%sodiumazide.
TLR1isa786aminoacidproteinwith18N-terminalleucine-richrepeatmotifs(LRRs)andacalculatedmolecularweightof84kDa.TLR1ismostcloselyrelatedtoTLR6andTLR10with68%and48%overallsequenceidentity,respectively.Invivo,twodifferentsizedtranscriptsforTLR1areobservedsuggestingthatthemRNAisalternativelysplicedtogeneratetwodifferentformsoftheprotein.TLR1mRNAisubiquitouslyexpressedandfoundathigherlevelsthantheotherTLRs.Ofthemajorleukocytepopulations,TLR1ismosthighlyexpressedbymonocytes,butisalsoexpressedbymacrophages,dendriticcells(DCs),polymorphonuclearleukocytes,B,T,andNKcells.
SPECIFICATIONSUMMARYAntigen:Syntheticpeptidecorrespondingto16aminoacidsneartheaminoterminusofhumanTLR1.
HostSpecies:Rabbit
AntibodyClass:Polyclonal
Preservatives:0.02%sodiumazide
ThisantibodyrecognizeshumanandmouseTLR1.
Westernblotting:useat1-2ug/ml.Abandofapproximately84kDaisdetected.
Immunohistochemistry:formalin-fixed,paraffin-embeddedtissues,useat5ug/ml.
Smallintestine:Formalin-fixedparaffin-embedded
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableat4oC(short-term)or
-70oC(long-term).
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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