productdatasheet
CatalogNo.:56511
Size:50ugpurifiedbyionexchangechromatographyinPBScontaining0.02%sodiumazide.Concentrationis1mg/ml.
TLR2isa784aaproteinwith19N-terminalleucine-richrepeatmotifs(LRRs)andamolecularweightof84kDa.TLR2ismostcloselyrelatedtoTLR6with31%overallaasequence.Invivo,twodifferentsizedtranscriptsforTLR2areobservedsuggestingthatthemRNAisalternativelyspliced.TLR2mRNAexpressionisobservedinbrain,heart,lung,andspleentissuesandishighestinPBLs,specificallythoseofmyelomonocyticorigin.RecentevidenceindicatesthatTLR2isrecruitedtophagosomesandmaybedirectlyinvolvedintheinternalizationofmicrobialproductsbycells.
SPECIFICATIONSUMMARYAntigen:Syntheticpeptidecorrespondingto14aminoacidsneartheaminoterminusofhumanTLR2conjugatedtoKLH.
HostSpecies:Rabbit
AntibodyClass:Polyclonal
Preservatives:0.02%sodiumazide
ThisantibodyrecognizeshumanandmouseTLR2.
Westernblotting:useat0.5-2ug/ml.Abandofapproximately84kDaisdetected.
Immunohistochemistry:formalin-fixed,paraffin-embeddedtissuesafterheat-inducedantigenretrievalinpH6.0citratebuffer.Useat2-5ug/ml.
Heartmuscle(FFPE)stainedwith#56511
Thesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplications.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Storeantibodyat4oC.Dilutepriortoimmediateuse.Avoidfreezing.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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