productdatasheet
CatalogNo.:56506
Size:50ugpurifiedbyantigenaffinitychromatographyinPBScontaining0.02%sodiumazide.
TLR6isa796aaproteincontaining20N-terminalleucine-richrepeatmotifs(LRRs)withamolecularweightof91kDa.TLR6ismostcloselyrelatedtoTLR1,TLR10,andTLR2with68%,46%,and31%overallaasequenceidentity,respectively.Invivo,TLR6transcriptisobservedinthymus,spleen,andlung.TLR6mRNAexpressionishighestinBcellsandmonocytes.TLR6formsaheterodimerwithTLR2.LikeTLR1,TLR6isthoughttospecifyorenhanceTLR2andcontributetoitssignalingcapABIlitiesthroughheterodimerization.
Antigen:Syntheticpeptidecorrespondingto13aminoacidsnearthecenterofhumanTLR6.
HostSpecies:Rabbit
AntibodyClass:Polyclonal
Preservatives:0.02%sodiumazide
ThisantibodyrecognizeshumanTLR6.
Forinvitroinvestigationaluseonly.Notfor
useintherapeuticordiagnosticprocedures.
APPLICATIONSWesternblotting:useat0.5-1ug/ml.Abandofapproximately91kDaisdetected.
Immunohistochemistry:formalin-fixed,paraffin-embeddedtissues,useat5ug/ml.
Thymus:Formalin-fixedparaffin-embedded
Lungalveolarmacrophages:Formalin-fixedparaffin-embedded.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Storeat4oC(short-term)or-70oC(long-term).
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