productdatasheet
CatalogNo.:56508
Size:50ugpurifiedbyantigenaffinitychromatographyinPBScontaining0.01%sodiumazide.Concentrationis1mg/ml.
TLR8isa1,041aaproteincontaining26N-terminalleucine-richrepeatmotifs(LRRs)withamolecularweightof120kDa.TLR8ismostcloselyrelatedtoTLR7andTLR9with43%and35%overallaasequenceidentity,respectively.Invivo,TLR8mRNAisexpressedinlung,placenta,spleen,lymphnode,bonemarrow,andPBLs,withhighestexpressionfoundinmonocytes.TLR8mayalsobelocalizedintracellularlyand,likeTLR7,bindsimidazoquinolineswhilethenaturalligandsarestillunknown.
Antigen:SyntheticpeptidecorrespondingtoaninternalregionofhumanTLR8.
HostSpecies:Rabbit
AntibodyClass:Polyclonal
Preservatives:0.01%sodiumazide
ThisantibodyrecognizeshumanandmouseTLR8.
Westernblotting:useat1:500-1:2,000.Abandofapproximately120kDaisdetected.ELISA:useat1:2,000-1:10,000.
Immunohistochemistry:formalin-fixed,paraffin-embeddedtissues,useat5ug/ml.
Lung,alveolarmacrophages:Formalin-fixedparaffin-embedded
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Storeat4oC(short-term)or-70oC(long-term).
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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