
DicerMonoclonalAntibody
PurifiedbyProteinGaffinitychromatography.
DicerisamemberoftheRNaseIIIfamilythatspecificallycleavesdouble-strandedRNAstogeneratemicroRNAs(miRNAs).Afterlongprimarytranscriptpri-miRNAsareprocessedtostem-loopedpre-miRNAsbyDrosha,pre-miRNAsaretransportedtothecytoplasmandfurtherprocessedbyDicertoproduce22-nucleotidematuremiRNAs.ThematuremiRNAthenbecomesapartoftheRNA-InducedSilencingComplex(RISC)andcanbindtothe3'UTRofthetargetmRNA.
Antigen:Fusionproteincorrespondingtoaa1638-1899ofmouseEndoribonucleaseDicer(accessionno.Q8R418).
HostSpecies:MouseAntibodyClass:IgG1SPECIFICITYThisantibodyrecognizeshuman,mouseandratDicer.
Immunoblotting:useat1ug/ml.Predictedmolecularweightis~215kDa.
#12532onratbrainlysate.
PositiveControl:ratbrainlysate.
Thesearerecommendedconcentrations.Endusersshoulddetermineoptimalconcentrationsfortheirapplications.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notintendedfordiagnosticortherapeuticapplications.