productdatasheet
CatalogNumber | Size |
13701P-5 | 5ug |
13701P-25 | 25ug |
13701P-1000 | 1000ug |
Formulation:Sterile-filteredcolorlesssolutioncontains20mMTris-HCl,pH7.5,1mMDTT,10%glycerol,and2mMEDTA.Purifiedbyproprietarychromatographictechniques.
Alpha-1-antitrypsin(A1AT)isaserineproteaseinhibitorthatinhibitsthecatalyticdomainofelastase,plasmin,Collagenase,thrombin,leucocyticproteases,trypsin,chymotrypsin,andplasminogenactivator.DefectsintheA1ATgenecanleadtoemphysemaorliverdisease.IncreasedlevelsofserumA1ATarefoundincasesoflungandprostatecancersandasanacutephaseresponsetotissuenecrosisandinflammation.
RecombinantHumanA1ATproducedin
E.coliisasingle,non-glycosylatedpolypeptidechaincontaining393amino
acids(aa25-418)withamolecularweightof44.4kDa.
SPECIFICATIONSUMMARYSource:EscherichiacoliPurity:Greaterthan90%asdeterminedbySDS-PAGE.Accessionnumber:P01009AminoAcidSequence:
MEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIDQNTKSPLFMGKVVNPTQK.
Althoughstableat4oCfor4weeks,productisbeststoredatorbelow-20oC.Forlong-termstorage,additionofacarrierprotein(suchas0.1%HSAorBSA)isrecommended.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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SanDiego,CA92127
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Phone858.675.2405
Fax858.592.1509
info@qedbio.com
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