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QED Bioscience/Recombinant Human Granulocyte Macrophage Colony Stimulating Factor (rHuGM-CSF)/45104P-20/1 Ea
RecombinantHumanGranulocyteMacrophage-ColonyStimulatingFactor(rHuGM-CSF)
CatalogNumber | Size |
45104P-5 | 5ug |
45104P-20 | 20ug |
45104P-1000 | 1000ug |
CatalogNumber | Size |
45104P-5 | 5ug |
45104P-20 | 20ug |
45104P-1000 | 1000ug |
ORDERINGINFORMATION
GM-CSFwasfirstidentifiedasagrowthfactorthatsupportsinvitrocolonyformationofgranulocyte-macrophageProgenitorcells.ItisproducedinresponsetoimmuneorinflammatorystimulibyactivatedTcells,Bcells,macrophages,mastcells,fibroblasts,andalveolarepithelialcells.GM-CSFisa22kDaprotein,144aminoacids,composedoffourbundlealphahelices.
RecombinanthumanGM-CSFproducedinE.coliisasingle,non-glycosylatedpolypeptidecontaining127aminoacidswithamolecularweightof14,477Da.
Accessionno.:P04141.1Purity:>98%asdeterminedbyRP-HPLCandSDS-PAGE.AMINOACIDSEQUENCEThefirstfiveN-terminalaminoacidsareAla-Pro-Ala-Arg-Ser.N-terminalmethionineisremovedenzymatically.
ED50bydose-dependentstimulationofproliferationofhumanTF-1cells(humanerythroleukemicindicatorcellline)is<0.1ng/mlwhichcorrespondstoaSpecificActivityof11,100,000IU/mg.
ReconstitutelyophilizedGM-CSFinsteriledistilledH2Oatnotlessthan100ug/ml.Thiscanbefurtherdilutedinotheraqueoussolutions.
Storelyophilizedproductdesiccatedbelow-18oC.Afterreconstitution,GM-CSFmaybestoredat4oCfor2-7daysandbelow-18oCforfutureuse.Forlongtermstorage,additionof0.1%humanserumalbuminorbovineserumalbuminisrecommended.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseindiagnosticortherapeuticprocedures.
