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QED Bioscience/Recombinant Human Hsp90 beta1/11106P-2/1 Ea
productdatasheet
CatalogNumber | Size |
11106P-2 | 2ug |
11106P-10 | 10ug |
11106P-100 | 100ug |
CatalogNumber | Size |
11106P-2 | 2ug |
11106P-10 | 10ug |
11106P-100 | 100ug |
ORDERINGINFORMATION
Formulation:Sterile-filteredcolorlesssolutionin20mMTris-Hcl,pH8.0,1mMEDTA,0.1MNaCl,1mMDTT,and10%
glycerol.Purifiedbyproprietarychromatographictechniques.
Hsp90β1,amemberoftheHsp90familyofmolecularchaperones,isinvolvedinmaintainingproteinhomeostasisinthesecretorypathwayandinintracellulartraffickingofpeptidesfromtheextracellularspacetotheMHCclassIantigen-processingpathwayofantigen-presentingcells.Hsp90β1haskeyrolesinsignaltransduction,proteinfolding,andproteindegradation.Itassociateswithseveralco-chaperonesinfoldingofnewlysynthesizedproteinsandrefoldingofdenaturedproteinsafterstress.Hsp90β1ishighlyexpressedinhumangastriccarcinomaBGC-823cellsthroughoutthecellcycle.
RecombinanthumanHsp90producedin
E.coliisasingle,non-glycosylatedpolypeptidecontaining819aminoacids(aa22-803)withamolecularweightof94.4kDa.Itisexpressedwitha37aminoacidHis-tagattheN-terminus.
Source:Escherichiacoli
Purity:Greaterthan90%asdeterminedbySDS-PAGEandRP-HPLC.
Accessionnumber:P14625
Aminoacidsequence:MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSMDDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL.
Storeat4oCifentirevialwillbeusedwithin2-4weeks.Storeatorbelow-20oCforlongerperiodsoftime.Additionofacarrierprotein(suchas0.1%HSAorBSAisrecommendedforlong-termstorage.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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