productdatasheet
Formulation:Sterile-filteredcolorlesssolutionin20mMTris-Hcl,pH8.0,0.5mMDTTand10%glycerol.Purifiedbyproprietarychromatographictechniques.
BACKGROUND
HspA9,amemeroftheHsp70family,encodesaheat-shockcognateproteinthatisinvolvedinthecontrolofcellproliferationandactsasachaperone.HspA9islocatedonchromosome5,bandq31,aregionthatisoftendeletedinmyeloidleukemiasandmyelodysplasia,makingitacandidatetumorsuppressorgene.HspA9suppressesnucleartranslocation,transcriptionalactivation,andcontrolcentrosome-duplicationfunctionsofp53.
RecombinanthumanHspA9producedinE.coliisasingle,non-glycosylatedpolypeptidecontaining654aminoacids(aa47-679)withamolecularweightof71kDa.Itisexpressedwitha20-aminoacidHis-tagattheN-terminus.
SPECIFICATIONSUMMARYCatalogNumber | Size |
11118P-10 | 10ug |
11118P-50 | 50ug |
11118P-1000 | 1000ug |
CatalogNumber | Size |
11118P-10 | 10ug |
11118P-50 | 50ug |
11118P-1000 | 1000ug |
Source:EscherichiacoliPurity:Greaterthan95%asdeterminedbySDS-PAGE.Accessionnumber:P38646Aminoacidsequence:
GSSHHHHHHSSGLVPRGSHMASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ.
Storeat4oCifentirevialwillbeusedwithin2-4weeks.Storeatorbelow-20oCforlongerperiodsoftime.Additionofacarrierprotein(suchas0.1%HSAorBSAisrecommendedforlong-termstorage.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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