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QED Bioscience/Recombinant Human Interleukin-1 Receptor Antagonist (rHuIL-1ra)/40101P-100/1 Ea
RecombinantHumanInterleukin-1ReceptorAntagoNIST(rHuIL-1RA)
Formulation:Sterile-filteredwhitelyophilizedpowderwithnoadditives.Purifiedbyproprietarychromatographictechniques.
Interleukin-1RAisamemberoftheInterleukin-1(IL-1)cytokinefamily.ItinhibitstheactivitiesofofIL-1alphaandIL-1betaandmodulatesavarietyofIL-1-relatedimmuneandinflammatoryresponses.Apolymorphismofthisgeneisreportedtobeassociatedwithanincreasedriskofosteoporoticfracturesandgastriccancer.
RecombinanthumanIL-1RAproducedinE.coliisanon-glycosylatedN-terminalmethionylformofthenaturally-occurringpolypeptidecontaining153aminoacidswithamolecularweightof17kDa.
SPECIFICATIONSUMMARYCatalogNumber | Size |
40101P-20 | 20ug |
40101P-100 | 100ug |
40101P-1000 | 1000ug |
CatalogNumber | Size |
40101P-20 | 20ug |
40101P-100 | 100ug |
40101P-1000 | 1000ug |
Source:Escherichiacoli
Purity:Greaterthan98%asdeterminedbySDS-PAGEandRP-HPLC.
Accessionnumber:P18510.1
Aminoacidsequence:ThesequenceofthefirstfiveN-terminalaminoacidsisMet-Arg-Pro-Ser-Gly.
ED50bydose-dependentinhibitionofIL-1stimulationofD10Scellsis0.5ng/mlwhichcorrespondstoaSpecificActivityof2,000,000IU/mg.
ReconstituteinsteriledistilledH2Otonotlessthan100ug/mlwhichcanbefurtherdilutedinotheraqueoussolutions.
STORAGEANDSTABILITY
Storedessicatedbelow-18oC.Afterreconstitution,storeat4oCfor2-7daysandbelow-18oCforfutureuse.Forlongtermstorageofthereconstitutedproduct,additionof0.1%humanserumalbuminorbovineserumalbuminisrecommended.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
