productdatasheet
CatalogNumber | Size |
12502P-5 | 5ug |
12502P-25 | 25ug |
12502P-1000 | 1000ug |
CatalogNumber | Size |
12502P-5 | 5ug |
12502P-25 | 25ug |
12502P-1000 | 1000ug |
ORDERINGINFORMATION
Formulation:Sterile-filteredsolutionin20mMTris,pH7.5,2mMEDTA,and20%glycerol.Purifiedbyproprietarychromatographictechniques.
PCNAislocatedinthenucleusandisacofactorofDNApolymerasedelta.
PCNAactsasahomotrimerandhelpsinprocessingofleADIngstrandsynthesisduringDNAreplication.InreactiontoDNAdamage,PCNAisubiquitinatedandparticipatesintheRAD6-dependentDNArepairpathway.TwotranscriptvariantsencodingthesameproteinhavebeenfoundforPCNAgene.PCNAisexpressedduringlateG1phase,Sphaseofmitosis,andpersistsuntiltheendoftheMphase.
PCNAcanbeinducedbyUVirradiation.
RecombinantHumanPCNAproducedin
E.coliisasinglenon-glycosylatedpolypeptidechaincontaining261aminoacidswithamolecularweightof28.8kDa.
Source:EscherichiacoliPurity:Greaterthan95%asdeterminedbySDS-PAGE.Accessionnumber:P12004Aminoacidsequence:
MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEGS.
Althoughstableat4oCfor4weeks,productisbeststoredatorbelow-20oC.Additionofacarrierprotein(suchas0.1%HSAorBSA)isrecommendedforlong-termstorage.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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SanDiego,CA92127
TollFree800.929.2114
Phone858.675.2405
Fax858.592.1509
info@qedbio.com
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