productdatasheet
Formulation:Sterile-filteredcolorlesssolution(1mg/ml)in20mMTris-HCl,pH8.0,and10%glycerol.Purifiedbyproprietarychromatographictechniques.
SERPINH1isamemberoftheserpinsuperfamilyofserineproteinaseinhibitorswhoseexpressionisinducedbyheatshock.Asamolecularchaperone,itlocalizestotheendoplasmicreticulumlumenandbindscollagen,thusparticipatinginthematurationofcollagenmolecules,facilitatingthefoldingandassemblyofprocollagenmolecules,retainingunfoldedmoleculeswithintheER,andassistinginthetransportofcorrectlyfoldedmoleculesfromtheERtotheGolgiapparatus.AutoantibodiestoSERPINH1havebeenfoundincasesofrheumatoidarthritis.
RecombinanthumanSERPINH1producedinE.coliisasingle,non-glycosylatedpolypeptidecontaining439aminoacids(aa18-417)withamolecularweightof48.9kDa.Itisfusedtoa37-aminoacidHis-tagattheN-terminus.
CatalogNumber | Size |
11125P-10 | 10ug |
11125P-50 | 50ug |
11125P-1000 | 1000ug |
CatalogNumber | Size |
11125P-10 | 10ug |
11125P-50 | 50ug |
11125P-1000 | 1000ug |
Source:EscherichiacoliPurity:Greaterthan90%asdeterminedbySDS-PAGE.Accessionnumber:P50454Aminoacidsequence:
RGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSHMAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDEL.
Storeat4oCifentirevialwillbeusedwithin2-4weeks.Storeatorbelow-20oCforlongerperiodsoftime.Additionofacarrierprotein(suchas0.1%HSAorBSA)isrecommendedforlong-termstorage.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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