CatalogNo.Size

50184P-22ug

50184P-1010ug

50184P-5050ug

50184P-100100ug

50184P-10001000ug

CCL19(alsoknownasMacrophageInflammatoryProtein-3beta,MIP-3β,andEBI1ligandchemokine,ELC)directschemotaxisofdendriticcellsandcertainB-andT-lymphocytes,butnotmonocytesorgranulocytes.ItisconstitutivelyexpressedinthymusandlymphnodesandbindsspecificallytotargetcellsexpressingthereceptorCCR7.Asahomeostaticchemokine,itsprimaryphysiologicalroleisthoughttobeinthenormalrecirculationandhomingoflymphocytes.However,CCL19canalsobeproinflammatoryandisimplicatedinpost-HIVinfectionresponses.

Source:RecombinanthumanCCL19producedinE.coli(accessionno.Q99731).

ProteinSequence:GTNDAEDCCLSVTQKPIPGYIVRNFHYLLIKDGCRVPAVVFTTLRGRQLCAPPDQPWVERIIQRLQRTSAKMKRRSS

MolecularMass:8.8kDabyMassSpec.

Purity:>97%bySDS-PAGE

Activity:EC50=30nMdeterminedbycalciumfluxwithrecombinanthumanCCR7.

EndotoxinLevel:<0.01EUper1ugofproteinbyLALmethod.

Form:Lyophilized.

CarrierProtein:None.

Reconstitution:Recommendedat100ug/mlinsteriledistilledwater.

StABIlityandStorage:12monthsfromdateofreceipt,-20oCto-70oC,assupplied.

1month,2oCto8oC,understerileconditionsafterreconstitution.

3months,-20oCto-70oC,understerileconditionsafterreconstitution.

Forinvitroinvestigationaluseonly.Notforuseindiagnosticortherapeuticprocedures.