CatalogNo.Size#1112Anti-HIVCo-ReceptorCCR5Antibody50181PB-22ug
50181PB-1010ug
50181PB-5050ug
50181PB-100100ug
CCL5,alsoknownasRegulatedonActivation,NormalT-cellExpressedandSecreted(RANTES),isaproinflammatorychemokinethatinducesmigrationandactivationofleukocytes,andisalsoimpliedinHIVinfection.CCL5bindstocellsurfacereceptorsCCR1,CCR3,CCR4,andCCR5.
ItsBIOLOGicaleffectsonleukocyteactivationandHIVinfectionsisdependentuponconcentrationandonthebindingofcellsurfaceglycosaminoglycans.
DESCRIPTIONDESCRIPTIONSource:RecombinanthumanCCL5,producedinE.coli,correspondstoaa24-91(accessionno.P13501).
Modification:Biotinylated
ProteinSequence:SPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAVVFVTRKNRQVCANPEKKWVREYINSLEMS
Purity:>97%bySDS-PAGE
Activity:EC50=0.25-0.50nMdeterminedbyMigrationAssayincellsexpressingrecombinantCCR5.
EndotoxinLevel:<0.01EUper1ugofproteinbyLALmethod.
Form:Lyophilized.
CarrierProtein:None.
Reconstitution:CentrifugetubepriortoresUSPending.Recommendedat100ug/mlinsteriledistilledwater.
StABIlityandStorage:12monthsfromdateofreceipt,-20oCto-70oC,assupplied.
1month,-20oCto-70oC,understerileconditionsafterreconstitution.Bestifusedimmediatelyafterreconstitution.
Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseindiagnosticortherapeuticprocedures.
