CatalogNo.Size

50193P-22ug

50193P-1010ug

50193P-5050ug

50193P-100100ug

50193P-10001000ug

CXCL10,alsoknownasγ-interferon-inducIBLeprotein(IP-10),wasoriginallyidentifiedasanIFN-gamma-induciblegeneinendothelialcells,fibroblasts,andmonocytes.IP-10signalsthroughtheCXCR3receptortoattractTstronglymphocytesandmonocytes.Italsohasangiostaticandmitogenicpropertiesonvascularsmoothmusclecells.AdiversepopulationofcelltypesrapidlyincreasestranscriptionofmRNAencodingIP-10,suggestingthatIP-10mightbeakeymediatoroftheIFN-gammaresponse.

Source:RecombinanthumanCCL14isproducedinE.coli(accessionno.

P02778,aa22-98).

ProteinSequence:VPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP

MolecularMass:8.646kDabyMassSpec.

Purity:>97%bySDS-PAGE

Activity:EC50=6.3nMdeterminedbyMigrationAssayincellsexpressingrecombinantCXCR3.

EndotoxinLevel:<0.01EUper1ugofproteinbyLALmethod.

Form:Lyophilized.

CarrierProtein:None.

Reconstitution:Recommendedat100ug/mlinsteriledistilledwater.

StABIlityandStorage:12monthsfromdateofreceipt,-20oCto-70oC,assupplied.

1month,-20oCto-70oC,understerileconditionsafterreconstitution.Bestifusedimmediatelyafterreconstitution.

Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseindiagnosticortherapeuticprocedures.