CatalogNo.Size

50183P-22ug

50183P-1010ug

50183P-5050ug

50183P-100100ug

50183P-10001000ug

CCL28,alsoknownasMucosae-associatedEpithelialChemokine(MEC),issecretedbygastrointestinalandnon-intestinalmucosalcells.ItregulateschemotaxisofcellsexpressingsurfacereceptorsCCR3andCCR10.Thischemokineisconstitutivelyexpressedinthecolon,butitslevelscanbeincreasedbypro-inflammatorycytokinesandcertainbacterialproductsimplyingaroleineffectorcellrecruitmenttositesofepithelialinjury.CCL28hasalsobeenimplicatedinthemigrationofIgA-expressingcellstothemammarygland,salivarygland,intestineandothermucosaltissues.Ithasalsobeenshownasapotentialantimicrobialagenteffectiveagainstcertainpathogens,suchasGramnegativeandGrampositivebacteriaandthefungusCandidaalbicans.

Source:RecombinanthumanCCL28,producedinE.coli,correspondstoaa23-127(accessionno.Q9NRJ3).

ProteinSequence:ILPIASSCCTEVSHHISRRLLERVNMCRIQRADGDCDLAAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCHRKKHHGKRNSNRAHQGKHETYGHKTPY

MolecularMass:12.073kDabyMassSpec.

Purity:>97%

Activity:EC50=38nMdeterminedbyMigrationAssayinL1.2cellsexpressingCCR10.

EndotoxinLevel:<0.01EUper1ugofproteinbyLALmethod.

Form:Lyophilized.

CarrierProtein:None.

Reconstitution:Recommendedat100ug/mlinsteriledistilledwater.

StABIlityandStorage:12monthsfromdateofreceipt,-20oCto-70oC,assupplied.

1month,2oCto8oC,understerileconditionsafterreconstitution.

3months,-20oCto-70oC,understerileconditionsafterreconstitution.

Forinvitroinvestigationaluseonly.Notforuseindiagnosticortherapeuticprocedures.